The word "Divinely" and "Appointed" convey the sense that one is not in control of their own destiny? The biggest challenge is submitting to the will of God when you have no understanding as to why you are being lead in a certain direction. You have to learn to trust him, something which gets easier through the passage of time and by the experiences you gain by exercising your faith muscles.
The key lies in developing one's personal relationship with The Holy Spirit, this takes time and is not a one-off action but a journey."Hijacked into Paradise," a song written by a good friend of mine Godfrey Birtill describes perfectly my experience when I received this intoxicating joy which flowed over me and erupted deep within me, taking me to places I never dreamed existed. I was swept along in an ecstasy which overwhelmed me at times," The Lord said to Peter that there would come a time in his life when the Spirit would lead him in paths he did not wish to tread. Divinely appointed places according to God's plan. I can't say that I have not wanted to be lead on this path, it has turned out to be a glorious adventure over the last twenty something years.
father God thank you for your plan and your appointed times for my life, even though I may not understand the direction you are leading me, I submit to you. Take me deeper in my relationship with You.